Across Dr. P. Gnana's diverse oeuvre, the underlying message remains consistently focused on human experience and spirituality. His art serves as an intimate exploration of life's fundamental connections and vulnerabilities. The primary and enduring theme is love in its many forms, from the profound maternal love depicted in the "Mother and Child" series to the devotion seen in "Radha-Krishna" pairings alongside the acknowledgement of the fragility and necessity of protection in all relationships and companionships.

Gnana's visual language deeply reflects his Indian heritage, utilizing intricate patterns and a palette that evokes a strong connection to spirituality and raw human emotion. This powerful blend of culture and feeling ensures his works are not only visually captivating but also thought-provoking, grounding his contemporary artistic approach in timeless, universal narratives.

His painting style is a dynamic fusion of traditional Indian artistic heritage and contemporary mixed-media experimentation. His canvases primarily feature a powerful, stylized, semi-figurative approach, where recurring motifs like the cow and Hindu deities act as vessels for his core themes of love, devotion, and human resilience. Gnana builds rich visual texture through collage, often layering materials like fabric (batik) and paper with oil or acrylic paint, demonstrating his mastery in bridging classical forms with the innovative processes of urban art-making.

His color palette is deliberately vibrant and energetic, directly influenced by the spiritual and emotional richness of his culture. He employs bright, earthy hues alongside the frequent use of gold leaf to infuse his works with a sense of sanctity and luminescence. Gnana views this dynamic use of colour not just as decoration, but as the "basic source of energy" necessary to vividly express the metaphysical dimensions of his subjects, ensuring his paintings are both visually striking and profoundly evocative.